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| Guimarães,Geovani Pereira; Reis,Mysrayn Yargo de Freitas Araújo; Silva,Dayanne Tomaz Casimiro da; Mendonça Junior,Francisco Jaime Bezerra; Converti,Attílio; Pessoa Jr,Adalberto; Damasceno,Bolívar Ponciano Goulart de Lima; Silva,José Alexsandro da. |
| Fungal infections have become a major problem of worldwide concern. Yeasts belonging to the Candida genus and the pathogenic fungus Cryptococcus neoformans are responsible for different clinical manifestations, especially in immunocompromised patients. Antifungal therapies are currently based on a few chemotherapeutic agents that have problems related to effectiveness and resistance profiles. Microemulsions are isotropic, thermodynamically stable transparent systems of oil, water and surfactant that can improve the solubilization of lipophilic drugs. Taking into account the need for more effective and less toxic drugs along with the potential of thiophene derivatives as inhibitors of pathogenic fungi growth, this study aimed to evaluate the antifungal... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Antifungal susceptibility; Cryptococcus neoformans; Microemulsion; Thiophene derivatives. |
| Ano: 2014 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822014000200024 |
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| Parahym,Ana Maria Rabelo de Carvalho; Rolim Neto,Pedro José; Silva,Carolina Maria da; Domingos,Igor de Farias; Gonçalves,Sarah Santos; Leite,Edinalva Pereira; Morais,Vera Lúcia Lins de; Macêdo,Danielle Patrícia Cerqueira; Lima Neto,Reginaldo Gonçalves de; Neves,Rejane Pereira. |
| We report a case of invasive infection due to Saprochaete capitata in a patient with hematological malignancies after chemotherapy treatment and empiric antifungal therapy with caspofungin. Although severely immunocompromised the patient survived been treated with amphotericin B lipid complex associated with voriconazole. |
| Tipo: Info:eu-repo/semantics/report |
Palavras-chave: Invasive infection; Saprochaete capitata; Geotrichum capitatum; Hematological malignancies; Antifungal susceptibility. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000200527 |
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| Neufeld,Paulo Murillo; Melhem,Marcia de Souza Carvalho; Szeszs,Maria Walderez; Ribeiro,Marcos Dornelas; Amorim,Efigênia de Lourdes Teixeira; Silva,Manuela da; Lazéra,Marcia dos Santos. |
| One hundred and forty-one Candida species isolated from clinical specimens of hospitalized patients in Rio de Janeiro, Brazil, during 2002 to 2007, were analized in order to evaluate the distribution and susceptibility of these species to fluconazole. Candida albicans was the most frequent species (45.4%), followed by C. parapsilosis sensu lato (28.4%), C. tropicalis (14.2%), C. guilliermondii (6.4%), C. famata (2.8%), C. glabrata (1.4%), C. krusei (0.7%) and C. lambica (0.7%). The sources of fungal isolates were blood (47.5%), respiratory tract (17.7%), urinary tract (16.3%), skin and mucous membrane (7.1%), catheter (5.6%), feces (2.1%) and mitral valve tissue (0.7%). The susceptibility test was performed using the methodology of disk-diffusion in agar... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Candida; Fluconazole; Antifungal susceptibility; Disk diffusion method. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822015000200477 |
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| Mnge,P.; Okeleye,B.I.; Vasaikar,S.D.; Apalata,T.. |
| Candida species are the leading cause of invasive fungal infections, and over the past decade there has been an increased isolation of drug resistant Candida species. This study aimed to identify the species distribution of Candida isolates and to determine their unique antifungal susceptibility and resistance patterns. During a cross-sectional study, 209 Candida isolates (recovered from 206 clinical samples) were collected and their species distribution was determined using ChromAgar Candida. The Vitek-2 system (Biomerieux, South Africa) was used to determine minimum inhibitory concentrations (MICs) to azoles (fluconazole, voriconazole), echinocandins (caspofungin, micafungin), polyenes (amphotericin B) and flucytosine. Four species of Candida were... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Candida species; Distribution; Antifungal susceptibility; Identification; South Africa. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000600702 |
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